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了解空气污染对ILD至关重要的分子机制

一分赛车2020nian7yue1ri-genjufabiaodeyipianxinwenzhang,bixukaizhangengduoyanjiulaiyanjiukongqiwuranduijianzhixingfeibing(ild)huanzhebiaoguanjiyinzudezuoyong,yibianzhidingchujiangzheixiewuranwudeyingxiangjiangzhizuididecelvezaimeiguoxiongkexuehuide《meiguohuxiyuzhongzhengjianhuyixuezazhi》shangzaixianfabiao。

ildshiyizuyanzhongdehuxidaojibing,qizhongzuichangjiandeshitefaxingfeixianweihua(ipf),gaibinghuidaozhifeizuzhibanhenxingcheng。biaoguanjiyinzuyouhuahewuhedanbaizhizucheng,zheixiehuahewuhedanbaizhijiangzishenfuzheyudna,yidiaojieqigongnengbingyingxiang“dakai”huo“guanbi”naxiejiyin。zhurukongqiwuranzhileidehuanjingbaoluzaigaibianbiaoguanyichuanyinsuzhongqizheguanjianzuoyong,zheishizheixiebaolukenengyouzhuyujibingfazhandeyizhongfangshi。

一分赛车yixueboshigillian c. goobiehehezhuzhezai“kongqiwuranhejianzhixingfeijibing: dingyibiaoguanjiyinzuxiaoying”zhonghuigulekongqiwuranduiildheqitahuxixitongjibingdeyingxiangdeyanjiu,ildzhongbiaoguanjiyinzudedangqianzhishishuipingyijiruheyingyongbiaoguanyichuanxuefangfalailejiekongqiwuranduiildhuanzhedeyingxiang。

一分赛车renleiyichuanxuexiboshishenggoobieboshishuo: “yifensaicherengchuyujiangkongqiwurandingyiweilinchuangweixianyinsudezaoqijieduan,zheishiyigexuyaojinyibuyanzhengdelingyu,ranhoucainengwanquanjinxinghouxudejiliyanjiu。”pizibaodaxuegonggongweishengyanjiushengyuan。“weilelianghuayinbaoluyukongqiwuranerduibiaoguanjiyinzudebianhuaduiilddefazhanyijizaizheixieqingkuangxiabulianghouguodeyingxiang,yifensaicheshouxianxuyaoduilinchuangyanjiujinxingkekaodepinggu。”

goobieboshirenwei: “yifensaichejijiangdadaozugoumingquedingyizheixiexiaoguopinggudedibu,youqishizaitefaxingfeixianweihua(ipf)zhong,yijiangzheiyizhishiyingyongyugengduodefenzihejizhiyanjiu。rengrancunzaijudachajuzailinchuangyanjiulingyuquedingkongqiwuranduiqitafeiipfxingshideilddeyingxiang。”

一分赛车kongqiwuranduimanxingzusaixingfeijibing(copd)hexiaochuandeyingxiangyidedaochongfenzhengshi,danshi,duiildhuanzhedeyingxiangshangbushifenqingchu。jinguankexuejiamenzhidaozhiyehehuanjingwuranwudebaoluyouzhuyuilddefazhanhefazhan,danqijizhishangbuqingchu。

一分赛车zuozhehuiguleyouguanbaoluyukongqiwuranyuduiildhuanzhedefumianjiankangyingxiangzhijianguanxidekexuewenxian。liru,duijiankanggetideyixiangyanjiufaxian,zhangqibaoluyueryanghuadanyufashengjianzhixingfeibuyichang(ila)dejilvgenggao,houzheshichengshudeilddexianzhao。duijiankanggetidelingyixiangyanjiufaxian,zhangqibaoluyuyuansutanyuilaheilajinzhandejilvzengjiayouguan。jinguanxuyaojinyibuyanjiu,danildzhongkenengshejideqitawuranwubaokuoxikeli,chouyangheeryanghuadan。

一分赛车zuozheyanjiulexuduoyanjiu,zheixieyanjiucongfenzishuipingxianshilexiaochuan,copdhekongqiwuranzhijiandeguanxi。tamenjixutaolunzaiilaheilddecileiyanjiuchengweixianshizhiqianbixucaiqudebuzhou,yijizaiildsshi200duozhongbutongjibingdeqingkuangxiaduiyizuxiangguanjibingjinxingcileiyanjiusuoshejidebingfazheng。tamenhaitaolunleqijinweizhiguanyufeibujibingdebiaoguanyichuanxueyanjiudejuxianxing。goobieboshijiqitongshichanmingleildbiaoguanyichuanyanjiudebiyaochububuzhou,liru,chanminglewaizhouxueyufeizuzhizhongbiaoguanyichuanmoshizhijiandeguanxi。zheixieleixingdeyanjiujiangshiyanjiurenyuannenggoutansuozheixiemoshiruhesuikongqiwuranbaoluerbianhua。

gubiboshishuo: “yifensaicherenweikongqiwuranshidangjinquanqiumianlindezuiyanzhongdegonggongweishenghehuanjingweijizhiyi。”“tabujinzaochengmeinianshubaiwandeguozaosiwang,erqiezheixiesiwangduishehuijingjidiweijiaodiheshaoshuzuyidegetizaochenglebuchengbilideyingxiang。dangwuzhijishiyishenghekexuejiamenshenruyanjiujiangkongqiwuranyumanxingbinglianxiqilaidejizhijichu。zheiyouqizhongyao。zaiilddenggaosiwanglvhebinglishenglibumingquedemanxingjibingzhong,wuranbaolukenengzaijibingdefazhanhejinchengzhongqizhongyaozuoyong。yifensaicherenwei,zheiyiyanjiulingyubujinduijibingyufang,duicujinhuanjingzhengyihefazhanjuyouzhongyaoyiyi。jiankangpingdeng。”

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